Cinnamic acids and derivatives
Cayman Chemical FerulIc AcId methyl esTR 500mg
A lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes; at 10-25 UG/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces NO generation from LPS-stimulated macrophages
Medchemexpress LLC Cinnamamide | 621-79-4 | MFCD00008033 | 98.6% | 147.17 | C9H9NO | 1 ML
Cinnamamide (CAS 621-79-4) is an organic compound supplied as a 10 mM solution in a 1 mL vial for research use. It is used as a biochemical reagent in life-science studies, assay development, and synthetic chemistry applications.
- Ready-to-use 10 mM solution format.
- Convenient 1 mL vial for small-scale experiments.
- Suitable for biochemical and life-science research applications.
- Commonly used as a reference compound or substrate in assays.
- Reported high purity; verify exact specification on the SDS.
Bruker Daltonics alpha-Cyano-4-hydroxycinnamic acid | 28166-41-8 | MFCD00004204
alpha-Cyano-4-hydroxycinnamic acid | Mol Wt: 189.17 | 28166-41-8 | MFCD00004204
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 50 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus and reduces the activation of the IL-12 p40 gene. In vivo therapy with A1 leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice.
- Target: IL-12 production inhibitor
- Dose-dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM
- Significantly weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
- Useful for differentiating TK-mediated effects of tyrphostins from other non-specific effects
Medchemexpress LLC Methyl 4-hydroxy-3-methoxycinnamate | 2309-07-1 | MFCD00017208 | 99.9% | 208.21 g·mol⁻¹ | C11H12O4 | 500 MG
Ferulic acid methyl ester (methyl ferulate) is the methyl ester derivative of ferulic acid (CAS 2309-07-1). It is used as a research reagent with reported antioxidant and anti-inflammatory activity and has been reported to affect p38 MAPK; supplied for biochemical and cellular studies at high purity.
- Methyl ester derivative of ferulic acid.
- Reported antioxidant and anti-inflammatory activity.
- Reported activity in p38 MAPK assays.
- High purity suitable for biochemical and cellular research.
- Soluble in common organic solvents such as DMSO.
- Available in small research pack sizes (for example, 500 mg).
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 100 MG
Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It causes a dose-dependent decrease of IL-12 p40 and blocks CD40L-induced translocation of NF-κB to the nucleus, reducing activation of the IL-12 p40 gene. This compound is a weaker inhibitor of TK, often used to differentiate TK-mediated effects from other non-specific effects.
- Inhibits CD40L-stimulated IL-12 production
- Reduces antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Useful for differentiating TK-mediated effects from non-specific effects
- For research use only
Medchemexpress LLC Ferulic acid methyl ester | 2309-07-1 | 99.9% | 208.21 g/mol | C11H12O4 | 1 G
Ferulic acid methyl ester (methyl ferulate) is the methyl ester derivative of ferulic acid used as a research reagent. It is reported as a p38 MAPK inhibitor with anti-inflammatory and antioxidant properties and is applied in studies of autophagy and neurological disease. The compound is cell membrane and brain permeable and modulates COX-2, p-p38, and p-JNK signaling.
- CAS number 2309-07-1
- Chemical formula C11H12O4
- Molecular weight 208.21 g/mol
- Typical purity ~99.9% (rounded)
- Available as solid and 10 mM solution in DMSO
- Reported p38 MAPK inhibitor with anti-inflammatory activity
- Useful for autophagy and neurological disease research
Medchemexpress LLC Ferulic acid methyl ester | 2309-07-1 | MFCD00017208 | 99.9% | 208.21 g/mol | C11H12O4 | 10 G
Ferulic acid methyl ester is the methyl ester derivative of ferulic acid used as a research reagent. It shows antioxidant and anti-inflammatory properties, is reported to inhibit p38 MAPK and modulate autophagy, and is suitable for biochemical and cell-based studies; batch-specific purity and safety documentation are available from the manufacturer.
- Methyl ester derivative of ferulic acid with antioxidant activity.
- Reported inhibitor of p38 MAPK and modulator of autophagy pathways.
- Cell membrane and brain permeable, suitable for cell-based assays.
- High batch-specific purity with certificate of analysis and SDS documentation available.
- Available in multiple pack sizes for research use, including a 10 g pack.
Medchemexpress LLC M-carboxycinnamic acid bishydroxamide | 174664-65-4 | MFCD03453553 | 98.0% | 222.20 g·mol⁻¹ | C10H10N2O4 | 10 MG
m-Carboxycinnamic acid bishydroxamide (CBHA) is a small-molecule histone deacetylase (HDAC) inhibitor supplied for research use. It inhibits HDAC1 and HDAC3 with reported ID50 values of approximately 10 nM and 70 nM, respectively, and has been reported to induce apoptosis and suppress tumor growth in experimental models.
- Potent HDAC inhibitor with reported ID50 ≈ 10 nM (HDAC1) and ≈ 70 nM (HDAC3).
- High purity (98.0%).
- Molecular formula C10H10N2O4 and molecular weight 222.20 g·mol⁻¹.
- Suitable for biochemical and cell-based assays.
- Demonstrated induction of apoptosis and tumor-growth suppression in studies.
- Supplied as a research-grade chemical for laboratory use.